منابع مشابه
RNAs as chaperones.
Recently, we found that RNA is a remarkably powerful chaperone that can bind to unfolded proteins and transfer them to Hsp70 for refolding. Combined with past studies on RNA-chaperone interactions, we propose a model for how chaperone RNA activity may contribute to the cellular response to stress.
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Cancer is a devastating disease that has affected millions of people, consumed tremendous efforts in the treatment/care and is incurable. Statistics from www.seer.cancer.gov show 14,140,254 people were living with cancer in 2013 in US with 1,685,210 new cases projected and 595,690 estimated deaths to occur due to cancer in 2016. Number of people surviving cancer (measured as 5-year survival rat...
متن کاملDo nucleic acids moonlight as molecular chaperones?
Organisms use molecular chaperones to combat the unfolding and aggregation of proteins. While protein chaperones have been widely studied, here we demonstrate that DNA and RNA exhibit potent chaperone activity in vitro Nucleic acids suppress the aggregation of classic chaperone substrates up to 300-fold more effectively than the protein chaperone GroEL. Additionally, RNA cooperates with the Dna...
متن کاملChaperones as parts of cellular networks.
The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. Molecular chaperones usually have many first and second neighbors in protein-protein interaction networks and they play a prominent role in signaling and transcriptional regulatory networks of the cell. Chaperones may uncouple prote...
متن کاملAging cellular networks: chaperones as major participants.
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which sequester and repair damaged proteins. In order to link the network approach and chaperones with the aging process, we first summarize the properties of aging networks suggesting a "weak link theory of aging". This theory suggests that age...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2016
ISSN: 1547-6286,1555-8584
DOI: 10.1080/15476286.2016.1247147